尼莫地平与硝苯啶治疗原发性高血压病的比较50例

Comparison between nimodipine and nefidipine therapy of essential hypertension in 50 patients

原发性高血压病50例,其中采用尼莫地平治疗者25例(男24例,女1例,年龄64±5a)剂量30-60mg,tid-qid.另25例用硝苯啶对照治疗,其中男23例,女2例,年龄65±4a,剂量10-20mg,tid-qid。2组均以4wk为一个疗程。尼莫地平组总有效率92％,硝苯啶组为88％。2组自身对照t检验,P<0.01,组间比较,P>0.05。不良反应均轻微。

Random comparative method was taken in patients with essential hypertensive diseases using nimodipine and nifedipine. Twenty five patients (M 24, F 1; age 64+5 a) in the nimodipine group received 30-60 mg, tid-qid, and 25 patients (M 23, F 2; age 65+4 a) in the nifedipine group received 10-20 mg, tid-qid, 4 wk as a course of treatment. The results showed that total response rate was 92% in nimodipine group and 88% in nifedipine group (P>0.05). In both groups the blood pressure decreased markedly (P<0.01), and adverse effects were mild.