可乐定用于戒烟

Clonidine on cigarette withdrawal symptoms

可乐定用于烟龄5a以上愿戒烟者23例,男21例,女2例;年龄46±11a;d1-2服1片(75μg),d3-11服1片bid,d12-13服1片qd,d14-15服0.5片qd,为一个疗程。减轻或消除戒烟症状,包括烟欲、焦虑不安、紧张急躁和精神不集中等。有效率91％,戒断率74％,随访重抽率22％,失败率26％。无效2例,占9％。可乐定可作为戒烟辅助药物。

A total of 23 smokers (M 21, F2, age 46+11 a) who smoked more than 5 a and wished to abandon were given clonidine hydrochloride 75ug qd on d 1-2; 75 ug bid on d 3-11, 75 /u-g qd on d 12-13 and 37.5ug qd on d 14-15. It decreased the withdrawal symptoms, including craving, anxiety, irritability, and difficulty in concentration. There was a 91% response rate, a 74% success rate but a 22% recurring ra.te and a 26% failure rate. The results provide evidence for efficacy of clonidine as an aid to give up smoking.