癫痫患者苯妥英钠血药浓度与眼球震颤的关系

Relationship between serum phenytoin concentration and nystagmus in epileptics

观察32例(男20,女12,年龄32±6a)癫痫患者眼球震颤出现及消失与苯妥英钠血浓度的关系,发现(1)出现眼球震颤的血药浓度为37±6μg/mL,提示药物过量;(2)眼球震颤出现在眼球偏斜角度的大小与苯妥英钠血浓度有关,浓度越高,角度越小,在≤45°组为48±3μg/mL,在>45°组则为35±5μg/mL;(3)眼球震颤消失时的血药浓度在20μg/mL左右。

The relationship between the appearance and disappearance of nystag- mus and serum phenytoin concentration was studied in 32 epileptics (M 20, F12,age 32+6 a). The result showed: (1) Nystagmus is the sign of overdosage with the serum concentrcatlon of 37+6/ug/mL; (2) The angle of eye deviation from midline during nystagmus was related to the serum drug concentration, the higher the concentration, the less the angle. The serum concentration was 48+3ug/mL in<45 group and 35+5 ug/mL in>45 group; (3) Nystagmus disappeared when the serum dr,ug-concentration was about 20ug/ml