复方丹参滴丸配合FAM方案治疗胃癌临床观察

Clinical Observation on Composite Salviae Dropping Pill Combined with FAM Regimen in the Treatment of Gastric Carcinoma

目的 :观察复方丹参滴丸对化疗期间中晚期胃癌患者疗效、生活质量及不良反应的影响。方法 :90例中晚期非小细胞胃癌患者随机分为两组 :观察组 (46例 )采用复方丹参滴丸加FAM方案 [5 氟尿嘧啶 (5 Fu)、阿霉素 (ADM )、丝裂霉素 (MMC) ]治疗 ,对照组 (44例 )采用单纯FAM方案化疗。对两组疗效、生活质量及不良反应进行评价。结果 :观察组和对照组近期疗效 (完全缓解加部分缓解加好转 )分别为 6 7.4 %和 4 3.2 % (P <0 .0 5 ) ,观察组生活质量高于对照组 (P <0 .0 5 ) ,而白细胞减少、恶心呕吐反应及心脏毒性均低于对照组 (均P <0 .0 5 )。结论 :化疗期间使用复方丹参滴丸有改善生活质量。

Objective:To observe therapeutic effect of Composite Salviae Dropping Pill(CSDP), its influence on life quality and toxicity in treating advanced gastric carcinoma patients during chemotherapy. Methods: Ninety patients with advanced gastric carcinoma were randomly divided to observation group(treated with FAM regimen combined with CSDP, n=46) and control group(treated only with FAM regimen, n=44). Therapeutic effect, life quality of the patients and toxicity of CSDP were observed. Results: The objective response rate(CR+PR) was 67.4% in observation group, which was higher compared to 43.2% in group contrast(P<0.05).Life quality of observation group was better than that of control group(P<0.05). Leukopenia, nausea, vomiting, cardiac toxicity in observation group were less serious than those in control group(P<0.05). Conclusion: CSDP can obviously improve life quality of the patients with advanced gastric carcinoma and decrease side effects of chemotherapy.