摘要
目的 :探讨胃病患者黄苔与胃粘膜组织细胞凋亡之间的关系。方法 :选取黄苔胃病患者 6 2例 ,采用免疫组化法与 6 3例白苔胃病患者进行对照 ,采用免疫组化法检测胃粘膜增殖细胞核抗原 (PCNA)、p5 3、bcl 2、fas凋亡基因相关蛋白。结果 :黄苔患者 p5 3、fas表达均明显高于白苔患者 (均P <0 .0 5 ) ,而PCNA、bcl 2表达则与白苔患者差异均无统计学意义 (均P >0 .0 5 )。结论 :黄苔胃病患者伴有促凋亡基因相关蛋白的过度表达 。
Objective:To study the relation between the yellow tongue coating and the cell apoptosis of gastric mucosa in patients with gastric diseases.Methods:In gastric disease patients with yellow tongue coating, apoptotic genes and their related proteins including PCNA, p53, bcl 2 and fas were measured and compared with those in gastric disease patients with white tongue coating. Results:Expression of p53 and fas in gastric disease patients with yellow tongue coating was higher than those with white tongue coating, while the expression of PCNA and bcl 2 in patients with yellow tongue coating was not significantly different from those with white tongue coating. Conclusion: Yellow tongue coating is one of the most sensitive remarks which mean active infection in stomach, and its cell damage is related to the overexpression of p53 and fas.
出处
《中国中西医结合消化杂志》
CAS
2004年第1期13-14,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion