曲唑酮与文拉法辛治疗抑郁症的对照研究

Comparison of trazodone and venlafaxine in the treatment of depression

目的 评价曲唑酮治疗抑郁症的临床疗效和副反应。方法 对 72例抑郁症患者随机分为曲唑酮组 (36例 )与文拉法辛组 (36例 )进行对照性研究 ,疗程 8周 ,采用汉密顿抑郁量表 (HAMD) ,汉密顿焦虑量表(HAMA)、临床总体印象量表 (CGI)及副反应量表 (TESS)评定疗效及副反应。结果 曲唑酮与文拉法辛的临床疗效相似 ,两组的显效率和有效率分别为 6 1%、78%与 6 1%、81% ,差异无显著性 (P >0 0 5 ) ,副反应两组间差异也无显著性 (P >0 0 5 )。结论 曲唑酮与文拉法辛相比 ,在治疗抑郁症方面 。

Objective The aim of this study was to explore the efficacy and side effects of trazodone in the treatment of depression.Methods A total of 72 outpatients who met CCMD-2-R criteria for depression were randomly assigned to trazodone(n=36)or venlafaxine(n=36)treatment for 8 weeks.The efficacy was measured with Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale (HAMA),and Clinical Global Impressions(CGI).The adverse effects were determined by the Treatment Emergent Symptom Scale(TESS).Results The efficacy rates of trazodone and venlafaxine were 78%and 81%respectively,and the marked improvement rates were both 61%.There was no significant difference between two groups in efficacy.The adverse effects had no difference in two groups.Conclusion It is suggested that trazodone was as same as venlafaxine in safty and efficacy.