原发性肝癌伴癌综合征的回顾性分析

Retrospective Analysis of Patients With Paraneoplastic Syndrome of Primary Liver Carcinoma

目的 探讨原发性肝癌伴癌综合征的发病率及与AFP水平和肿瘤体积大小的相关性。方法 182例原发性肝癌患者 ,根据有无伴癌综合征表现分为伴癌组与非伴癌组 ,分别比较两组AFP水平及肿瘤体积大小。结果 182例原发性肝癌患者中 ,3 6例 ( 19.8% )出现伴癌综合征表现 ,其中 3 1例有一种 ,5例有两种。伴癌组平均AFP值及肿瘤体积大小与非伴癌组比较 ,差异有显著意义 (P <0 .0 1)。结论 原发性肝癌可出现一种或多种伴癌综合征 ,AFP水平及肿瘤体积大小可作为原发性肝癌发生伴癌综合征的独立预测指标。

Objectives To explore the incidence rate of paraneoplastic syndrome of primary liver carcinoma, and the relationship with the size of tumor and the level of AFP. Methods Based on the clinical symptom, 182 patients with primary liver carcinoma were divided into paraneoplastic syndrome group and non-paraneoplastic syndrome group. The level of AFP and the size of tumor in two groups were detected. Results 36 patients appeared paraneoplastic syndrome. Among them, 31patients appeared one kind paraneoplastic syndrome, 5 patients appeared two kind paraneoplastic syndrome. The differences of the level of AFP and the size of tumor in two groups were significant. Conclusions Patients with primary liver carcinoma may appear one or two kind of paraneoplastic syndromes. The level of AFP and the size of tumor are effective for forecasting the paraneoplastic syndrome of primary liver carcinoma.