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人谷氨酸脱羧酶DNA疫苗的构建与鉴定 被引量:6

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出处 《中国免疫学杂志》 CAS CSCD 北大核心 2004年第2期125-126,共2页 Chinese Journal of Immunology
基金 国家自然科学基金资助项目 (NSFC3 0 170 44 0 )
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参考文献4

  • 1[1]Kaufman D L, Clare-Salzler M, Tian J et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes[J]. Nature,1993;366:69-72.
  • 2[2]Tisch R, Yang X D, Singer S M et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice[J].Nature, 1993;336: 72-75.
  • 3[3]Yoon J W, Yoon C S, Lim H W et al.Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells[J].Science,1999;284:1183-1187.
  • 4[4]Bu D F, Erlander M G, Hitz B C et al. Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene[J]. Proc Natl Acad Sci USA,1992;89:2115-2119.

同被引文献60

  • 1罗建华,周智广,蒋铁建,裴剑浩,李霞,何凌,孙曙光.人谷氨酸脱羧酶65 DNA疫苗预防非肥胖糖尿病小鼠糖尿病的机制探讨[J].中华医学杂志,2004,84(21):1791-1795. 被引量:8
  • 2宋新强,骆媛,王丹,刘曙光,刘金锋,袁方,薛红,刘楠,梁飞,孙玉英,奚永志.鸡Ⅱ型胶原基因疫苗pcDNA-CCOL2A1能有效治疗大鼠类风湿性关节炎[J].中国科学(C辑),2006,36(6):534-542. 被引量:4
  • 3[3]Yoon J W,Yoon C S,Lim H W,et al.Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells.Science,1999;284(5417):1183-1187
  • 4[4]Abiru N,Moriyama H,et al.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Nature,2005; 435(7039):220-223
  • 5[7]Li A F,Escher A.Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes.DNA Cell Biol,2003;22:227-232
  • 6[8]Glinka Y,De Pooter R,Croze F,et al.Regulatory cytokine production stimulated by DNA vaccination against an altered form of glutamic acid decarboxylase 65 in nonobese diabetic mice.J Mol Med,2003;81(3):175-184
  • 7[9]Gauvrit A,Debailleul M,Vu A T,et al.DNA vaccination encoding glutamic acid decarboxylase can enhance insulitis and diabetes in correlation with a specific Th2/3 CD4 T cell response in non-obese diabetic mice.Clin Exp Immunol,2004;137(2):253-262
  • 8[10]Tisch R,Wang B,Atkinson M A,et al.A glutamic acid decarboxylase 65-Specific Th2 cell clone immunoregulates autoimmune in nonobese diabetic mice.J Immunol,2001;166(11):6925-6936
  • 9[11]Quinn A,McInnerney M F,Sercarz E E,et al.MHC Class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity.J Immunol,2001; 167 (3):1748-1757
  • 10[12]Kim S K,Tarbell K V,Sanna M,et al.Prevention of type Ⅰ diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cslls.Proc Natl Acad Sci USA,2004; 101 (39):14204-14209

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