溃疡性结肠炎患者血浆P-选择素的检测及临床意义

Determination of plasma P-selection in patients with ulcerative colitis and their clinical significance

目的 观察溃疡性结肠炎患者血浆P 选择素的水平 ,并探讨其临床意义。方法 采用ELISA方法检测了2 8例溃疡性结肠炎活动期患者和 13例缓解期患者血浆P 选择素的含量。结果 溃疡性结肠炎活动期组患者血浆P 选择素的含量与正常对照组和溃疡性结肠炎缓解期组比较差异均具有显著性意义 (P <0 0 1) ,而缓解期组与正常对照组之间无显著性差异。活动期组患者血浆P 选择素的含量与病情的严重程度呈正相关。结论 P 选择素参与溃疡性结肠炎的发病 ,检测P 选择素对溃疡性结肠炎的病情及疗效评估具有一定的参考价值。

Objective To observe the levels of plasma P-selection(P-sel) and in patients with ulcerative colitis and to study the clinical significance of them. Methods the concentrations of P-sel in 18 patients with active ulcerative colitis and 13 relief ulcerative colitis were determined with ELISA method. Results The results shown that the levels of P-sel in active ulcerative colitis patients were markedly elevated and were correlated with the severity of the disease. But the levels of P-sel in relief ulcerative colitis patients have no difference with normal controls. Conclusion It is suggested that the occurrence and development of ulcerative colitis may be related to the increase of plasma P-sel. Measurement of levels of plasma P-sel and might therefore provide a tool for monitoring the clinical course and for gaiding the treatment of ulcerative colitis.