瘦素在多囊卵巢综合征诊治中的临床价值

The clinical value of the Leptin in the diagnosis and treatment to PCOS

目的 为探讨瘦素 (Leptin)在多囊卵巢综合征 (PCOS)发病中的作用及二甲双胍对PCOS的治疗效果。方法 对 2 5例PCOS患者服二甲双胍前及服二甲双胍 8～ 12周后 ,用放免法测定其血清瘦素 (Leptin)、空腹胰岛素 (IN) ;化学发光免疫分析法测定黄体生成素 (LH)、卵泡刺激素 (FSH)和睾酮 (T)及用己糖激酶方法测定空腹血糖 ;并取 2 5例排卵正常、无怀孕妇女进行对照。结果 治疗前PCOS组血糖、Leptin、IN、T、LH、FSH均明显高于正常对照组 (P <0 0 0 5 ) ,且Leptin与IN呈正相关 (r=0 84 2 6 ,P <0 0 5 ) ;治疗后除血糖无显著性下降外 ,Leptin、IN、T、LH水平均明显下降 (P <0 0 0 5 ) ,FSH也有所下降 (P <0 0 5 )。结论 瘦素在PCOS患者中异常升高 ,并可能参与其发病机制 ;瘦素可反映二甲双胍治疗PCOS的疗效。

Objective To discuss the Leptin action in PCOS episode and fluamine therapeutic effect on curing PCOS. Methods to choose 25 patients of PCOS before taking fluamine and after taking it for 8～12 weeks, then check their serum Leptin and IN with radio-immunity, take the level with chemiluminescence immune tcchnique and take the blood sugar of empty stomach with hexokinase method and then choose 25 cases of normal ovulation,unconceived women as contrast group.Results All of the PCOS patients blood sugar, Leptin, IN, T, LH, FSH are higher then normal women. Post-treatment, the level of Leptin, IN, T and LH phanero-descent, FSH decrease too, expect for blood sugar. Before treatment, Leptin is positive correlated with IN. Conclusion Leptin incease anomaly to PCOS, it may possibly participate the pathogenesis; Leptin can reflect fluamine effect in PCOS.