摘要
当一定强度的瞬态电磁脉冲作用于细胞时 ,在细胞膜上将形成瞬时微孔 ,可促进药物等大分子进入细胞内。本研究利用电穿孔现象结合抗癌药物治疗在昆明小鼠上接种和生长的 S- 180肉瘤 ,发现这种方法可以明显地抑制肿瘤细胞的生长。这种癌症治疗技术具有操作简单、容易控制、毒副作用小等优点 ,特别适用于浅表肿瘤的治疗。
In this paper is reported a new approach for the treatment of sarcoma——electroporation therapy. Electroporation can accelerate pharmacal molecules into cytoplasm by transient electromagnetic pulses. We have utilized the phenomenon of electroporation treating the S-180 sarcomas in the hind legs of the Kunming mice by intratumoral injection of anti-tumor agent at low dose. From the experiment, we learned that this approach can bring about remarkable effect. The technical procedure is easy to do and easy to control. Especially, it is useful in curing the flat tumor and has little untoward side effect. It deserves to be recommended as a new approach to treating the tumor in clinics.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2004年第1期69-71,共3页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 ( 60 0 710 2 4)
