α-烯丙基葡糖苷对聚甲基丙烯酸甲酯人工晶状体的表面修饰

Surface Modification of Poly Methyl Methacrylate Intraocular Lens by α-Allyl Glucoside

为了提高人工晶状体的生物相容性 ,降低表面细胞的黏附性 ,本实验采用等离子体引发聚合方法 ,在聚甲基丙烯酸甲酯 (PMMA)人工晶状体表面“在位聚合”修饰一层 α-烯丙基葡糖苷 (α- AG)。静态接触角、电子能谱分析、光学和力学指标及细胞黏附性测试等结果表明 :等离子体引发聚合所制备的 α- AG表面修饰的人工晶状体光学、力学指标均达到产品标准 ;经表面修饰的人工晶状体其亲水性提高 ,巨噬细胞的黏附性降低 。

A method for improving the biocompatibility of the intraocular lens (IOL) and reducing the cell attachment was adopted in this study. The α-Allyl glucoside was used for the surface modification of the poly methyl methacrylate (PMMA) IOL by way of plasma-induced in situ polymerization. The surfaces of the control and treatment IOLs were characterized by contact angle estimation and ESCA techniques. The resolution, diopter and anti-fatigue of loops were determined by physical and optical methods. Cell attachment on the surfaces was examined by light microscopy. The results indicated that all of the treatment groups had excellent physical and optical properties. The modification with the use of α-Allyl glucoside could improve the hydrophilicity of the anterior surface of the PMMA IOLs and reduce the cell attachment.