透明质酸在慢性牙周炎治疗中的作用

Clinical Study of Hyaluronic Acid in the Treatment of Chronic Periodontitis

目的 观察局部应用外源性透明质酸 (HA)对慢性牙周炎的临床疗效。方法 采用口内自身对照的研究方法。选择 2 0例慢性牙周炎患者的患牙 30 6颗 ,其中 15 0颗患牙为对照组 ,15 6颗为实验组。对照组患牙仅作洁刮治和根面平整 (SRP)。实验组患牙在行SRP后 ,龈下辅助给予 0 2 %透明质酸凝胶。观察两组患牙的菌斑指数、龈沟液流速、龈沟出血指数、牙周探诊深度和临床附着水平等临床指标的动态变化。结果 对照组和实验组患牙的各临床指标在治疗后均显著改善 ,实验组患牙龈沟液流速的下降显著快于对照组 (P =0 0 0 1) ,但其余临床指标两组间的差异无显著性。结论 本研究未发现HA结合SRP对治疗慢性牙周炎在牙周组织修复再生中有促进作用 ;

Objective Clinical effects in local application of hyaluronic acid (HA) adjunctive to scaling and root planing (SRP) were evaluated. Methods In this cross over design study 20 patients with chronic periodontitis were included. Plaque index, sulcus-fluid-flow-rate (SFFR), sulcus bleeding index, probing pocket depth and attachment level were monitored. All patients were treated with full mouth SRP, in addition a HA gel was administered subgingivally in the test site every week for 6 weeks. Results A statistically significant improvement of all clinical test parameters was observed in both groups (P<0 05). Clinically, no significant difference between test and control group could be found. However, the SFFR decreased significantly faster in the test group. Conclusion No post-inflammatory tissue regeneration could be achieved by the adjunctive use of HA gel to SRP in the patients with chronic periodontitis. Due to SFFR a control of local inflammation can be achieved quickly.