黄白口服液对安氟醚吸入麻醉致呼吸系统损伤的保护作用

Protective Effects of Huang Bai(黄白) Oral Solution on Respiratory Injury Ind uced by Inhalation Anethetic-Enflurane

目的 :探讨安氟醚吸入麻醉对呼吸系统的损伤机制及中药黄白口服液的保护作用。 方法 :观察安氟醚吸入麻醉对家兔肺毛细血管通透性 (12 5 I标记牛血清白蛋白法 )、肺灌洗液巨噬细胞超微结构、肺组织磷脂酶A2 活性以及肺组织形态结构的影响 ,观察灌服黄白口服液后上述指标的变化。 结果 :造模组肺毛细血管通透性显著高于正常对照组 (P <0 0 1) ,磷脂酶A2 活性也显著高于正常对照组 (P <0 0 1) ,肺泡巨噬细胞及肺组织形态结构与正常对照组相比明显受损。药物预防组肺毛细血管通透性及磷脂酶A2 活性均显著低于造模组 (均P <0 0 1)。药物预防组肺泡巨噬细胞及肺组织形态的损伤程度明显轻于造模组。 结论 :安氟醚吸入麻醉对肺组织形态及呼吸功能均有明显的损伤作用 。

ObjectiveTo clarify the pulmonary morphology and re spiratory injury induced by enflurane used as an anesthetic and the protective e ffects of Huang bai oral solutionMethodsIn experimental research,48 rabbits were divided into 3 grou ps:1.control group,2.positive control group(enflurane was used),3.experimental g roup(both Huang bai oral solution and enflurane were used).ResultsThe permeability of pulmonary capillaries and the activity of phospholipa se were significantly lower in the experimental group than in the positive contr ol group.The degree of ultramorphological injury of pulmonary macrophagocyte and pulmonary morphology was much higher in the positive control group than in cont rol group( P <0 01),but were lower in the experimental group than in the pos itiv e control group.Conclusion Enflurane used as an anaethetic has obvious damaging effect on pulmonary morphology and respiratory function an d Huang hai oral solution can be used to protect both pulmonary morphology and respiratory function from being damaged by enflurane.