丹芍汤治疗阴虚湿热型系膜增生性肾炎的临床观察

Clinical Observation of “Dan Shao Tang” in Treating Mesangial Proliferative Glomerulonephritis of Deficiency of Yin with Damp-heat Symptom

目的 :探讨丹芍汤对阴虚湿热型系膜增生性肾炎的作用。方法 :90例中医辨证为阴虚湿热型的系膜增生性肾炎随机分成两组 ,治疗组 5 4例以丹芍汤加西药治疗 ,对照组 36例单用西药治疗 ,3个月后观察两组的疗效及肾功能、蛋白尿、血尿、血脂等相关指标的变化情况。结果 :治疗组总有效率为 75 93% ,明显优于对照组 4 7.2 2 %(P <0 .0 1) ;治疗组在降低蛋白尿、血尿、改善肾功能及血脂代谢方面明显优于对照组 (P <0 .0 5 )。结论 :丹芍汤能有效治疗阴虚湿热型系膜增生性肾炎。

Objective: To explore the effect of “Dan Shao Tang”(DST) on mesangial proliferative glomerulonephritis(MsPGN) of deficiency of Yin with damp-heat symptom. Methods: 90 patients with MsPGN of deficiency of Yin with damp-heat symptom were randomly divided into two groups. 54 patients in treatment group were treated with DST and western medicine, and 36 patients in control group were treated only with western medicine. We observed the effect and indexes change including renal function, proteinuria, hematuria, lipid before and after treatment. Results: After three months treatment, the general effective rate in treatment group was 75.93%, which was markedly higher than that in control group (47.22%,P<0.01). Treatment group is obviously better than control group on decreasing proteinuria and hematuria, improving renal function, ameliorating lipid metabolism (P<0.05). Conclusion: DST is effective on MsPGN of deficiency of Yin with damp-heat symptom.