IL-8与iNOS在进展期胃癌组织中表达的意义

Expression of IL-8 and iNOS in advanced gastric carcinoma

目的 探讨IL 8和诱导型一氧化氮合酶 (iNOS)在胃癌组织中的表达以及二者之间的关系。方法 采用免疫组化sABC法 ,对 33例胃癌组织进行了IL 8和iNOS检测。结果 ①iNOS、IL 8在正常胃黏膜和肿瘤组织之间的表达有显著性差异 (P <0 .0 1 )。②iNOS、IL 8在病理分化不同的肿瘤组织中的表达无显著性差异 (P >0 .0 5 )。③IL 8、iNOS在癌组织中的表达具有相关性 (P <0 .0 1 )。结论 IL 8、iNOS在胃癌组织中表达明显上调 ,二者具有相关性 ,提示IL 8、iNOS可能在胃癌中起一定作用。

Objective To explore the expression of IL 8 and iNOS in gastric carcinoma tissue,and the relationship between IL 8 and iNOS.Methods Thirty three cases of gastric carcinoma were collected by using immunohistochemistry technique and the expression of IL 8 and iNOS were examined respectively.Results ①The expression of iNOS,IL 8 both had significant differences between the gastric carcinoma and the normal gastric tunica mucosa ( P <0.01).②The expression of IL 8 and iNOS had no difference among the various pathology type gastric carcinoma ( P >0.05).③The expression of iNOS had a positive correlation with the expression of IL 8( P <0.01).Conclusion Both of IL 8 and iNOS 's expression up regulate in the gastric cancer,and they have positive correlation with each other,which indicates that they may play roles in the gastric cancer.