IL-10-819位点基因多态性与汉族人群重度慢性牙周炎易感性相关性的研究

Association of IL-10-819 Polymorphism with the Susceptibility to Severe Chronic Periodontitis in Chinese Han Nationality.

目的 探讨IL 10启动子区基因多态性与重度慢性牙周炎易感性的关系。方法 收集 14 2名重度慢性牙周炎患者和 81名健康对照者的颊粘膜拭子 ,提取DNA ,采用ASO PCR方法检测IL 10 819位点基因多态性 ,比较重度慢性牙周炎患者和健康对照组中等位基因频率和基因型分布。结果 IL 10 819C/T等位基因频率和基因型分布在患者和对照组之间差异无显著性 (OR =1.377,P =0 .12 2 >0 .0 5 )。结论 IL 10 819位点基因多态性与汉族人群重度慢性牙周炎遗传易感性无相关关系。

Objective To investigate the association of IL-10-819 polymorphism with the susceptibility to severe chronic periodontitis (CP) in Chinese Han nationality. Methods DNA samples were collected with buccal swabs from 142 subjects with severe chronic periodontitis and 81 periodontal healthy control. IL-10-819 genotype was determined using allele-specific oligonucleotide polymerase chain reaction (ASO-PCR). The genotype distribution was analyzed. Results No significant differences were observed in the allele frequencies of IL-10-819C/T between controls and severe CP patients (OR=1.377, P=0.122>0.05). Conclusion The results suggest that IL-10-819 gene polymorphism is not associated with the susceptibility to severe chronic periodontitis in Han nationality in Sichuan area.