白细胞过滤器过滤前后血液质量变化观察及临床应用

The clinical application and observation of leukocyte filter

目的 探讨应用白细胞过滤器过滤前后血液质量的变化及其临床非溶血性输血反应发生率的程度。方法 将 4 0 0毫升 袋的全血用白细胞过滤器滤除白细胞。取过滤前后血液标本进行血液质量检测 ,并观察临床应用效果。结果 过滤后的白细胞去除率 98.5 8% (P <0 .0 0 1) ,红细胞计数、血红蛋白含量、红细胞膜渗透脆性试验及游离血红蛋白含量等均无明显变化 (P >0 .0 5 ) ,过滤前后红细胞的形态可见明显改变 (P <0 .0 1)。结论 白细胞过滤器可选择性地滤除白细胞 。

Objective To observe the changes of blood quality before and after being filtered by leukocyte filter and to observe to what degree it reduces the incidence of clinical non-hemolytic transfusion reactions.Methods The white blood cells were removed by leukocyte filter from whole blood (400ml/bag) , Samples before and after filtration were under gone blood quality detection and then observed the extent it reduced the incidence of clinical non-hemolytic transfusion reactions.Results Both of white blood cell count (WBC) and platelet count (PLT) are 0.09×10 9/L after filtration. The rate of filtration is more than 98.58%(P<0.001). There were no significant changes in RBC count, Hemoglobin concentration and erythrocyte osmotic fragility test, et al.Conclusion The leukocyte filtercan remove leukocyte with high efficiency and selectivity. It also can significantly reduce the incidence of clinical non-hemolytic transfusion reactions. [