1[1]Hochberg MC. Adult and juvenile rhcumatoid arthritis: current epidemiologic conccpts[J]. Epidemiol Rev, 1981,3:27 - 44
2[2]LaDuca JR,Gaspari AA. Targeting tumor necrosis factor alpha.New drugs used to modulate inflammatory diseases[J]. Dermatol Clin, 2001,19(4): 617 - 635
3[3]Maini RN, Brennan FM, Williams R, et al. TNF - alpha in rheumatoid arthritis and prospects of anti- TNF therapy[J].Clin Exp Rheumatol, 1993,11 Suppl 8: S173-S175
4[4]Lipsky PE, van der Heijde DM, St Clair EW, et al. Infiiximab and methotrexate in the treatment of rheumatoid arthritis. Anti -Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group [J]. N Et,gl J Med, 2000,343(22): 1594-1602
5[5]Brennan FM, Chantry D, Jackson A, et al. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin- 1 production in rheumatoid art hritis[J]. Lancet, 1989,2 (8657): 244-247
6[6]Charles P, Elliott MJ, Davis D, et al. Regulation of cytokines,cytokine inhibitors, and acute - phase proteins following anti-TNF -alpha therapy in rheumatoid arthritis[J]. J Immunol, 1999,163(3): 1521-1528
7[7]Shanahan JC, St Clair W. Tumor necrosis factor - alpha blockade:a novel therapy for rheumatic disease[J].Clin Inmunol,2002,103(3 Pt 1) :231-242
8[8]Elliott MJ,Maini RN, Feldmann M,et al. Randomised doubleblind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis[J].Lancet,1994,344(8930):1105-1110
9[9]Elliot t MI, Maini RN, Feldmann M, et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha[J].Arthritis Rheum, 1993,36(12): 1681-1690
10[10]Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis[J]. N Engl J Med,2000,343(22): 1586-1593
