吉诺通联合特布他林治疗喘息型慢性支气管炎的临床疗效

The clinical study of combining gelomyrtol with turbutaline to treat patients with chronic bronchitis

目的 观察吉诺通与特布他林配伍治疗喘息型慢性支气管炎的疗效。方法 118例患者被随机分为 3组 ,分别予以吉诺通口服、特布他林手持定量雾化 (MDI)吸入及吉诺通口服联合特布他林MDI吸入 ,观察 3组患者用药前、后的症状、体征、肺功能及血气分析的变化 ,同时对血电解质 ,心、肝、肾功能及胃肠道反应进行了监测。结果 吉诺通与特布他林联合用药组与单一用药组 3组疗效间差别有显著性意义 (P <0 0 1)。治疗后联合用药组与单一用药组的FEV1/FVC ( % )、VC ( % )、MBC ( % )的均值间差别均有显著性意义 (P <0 0 1) ;治疗后血气分析 ,联合用药组与单一用药组的各指标的均值间差别均有显著性意义 (P <0 0 1)。结论 吉诺通与特布他林联用能改善患者的通气功能 ,缓解病情 ,在应用支气管扩张药物的前提下应用吉诺通治疗能提高疗效。

Objective To observe the effect of combining Gelomyrtol with Turbutaline to treat patients with chronic bronchitis.Methods 118 patients with chronic bronchitis in acute stage were divided into three groups randomly.They were treated by Gelomyrtol,Turbutaline,Gelomyrtol associating with Turbutaline respectively,at the same time, the change of each groups′ effect such as symptom and sign,pulmonary function,blood gas analysis were observed.Results Gelomyrtol associated with Turbutaline compared with single drug could improve pulmonary ventilation function strikingly,they made FEV1/FVC(%)?VC(%)?MVV(%)increase (P<0 01),thus made PaO 2 increase,PaCO 2 reduce (P<0 01) and cough lessen,sputum expectoration promote.Conclusion Combing Gelomyrtol and Turbutaline could make pulmonary ventilation function improve,postpone patient′s condition to develop. The effect can be better by using Gelomyrtol based on the premise of using bronchodilatator.