乳腺癌耐药蛋白在乳腺癌原发灶和转移灶中表达的比较

Comparison of breast cancer resistance protein (BCRP) expression between primary and metastatic sites in breast carcinoma

目的 研究乳腺癌耐药蛋白 (breastcancerresistanceprotein ,BCRP)在乳腺癌原发灶和转移灶中的表达并进行比较 ,分析两者间有无差异及其与预后的关系。方法 采用免疫组织化学方法 (IHC)检测 4 4例手术切除的乳腺癌原发灶组织以及相应的淋巴结转移灶中 ,BCRP的表达。结果 (1 )BCRP在乳腺癌原发灶组织中的高表达率为 4 3.2 % (1 9/44例 ) ,在淋巴结转移灶中的高表达率为 5 6 .8% (2 5 /44例 ) ;(2 )经统计分析两者之间的表达并无差异 (P >0 .0 5 ) ;(3)Kaplan -Meier生存分析结果表明 ,乳腺癌原发灶和转移灶中BCRP表达与患者的无病和总生存期皆无关 (P >0 .0 5 )。结论 BCRP在乳腺癌组织中具有一定的表达水平 。

Objective The aim of the present study was to investigate the expression of breast cancer resistance protein (BCRP) in primary breast carcinoma and metastatic lymph nodes. Methods Expression of BCRP in 44 breast cancer patients including primary carcinoma and lymph nodes was determined by immunohistochemistry on formalin fixed, paraffin embedded tumor section.Results (1)The high expression of BCRP in primary breast carcinoma was observed in 19 of 44( 43.2 %) cases, the high expression of BCRP in metastatic lymph nodes was observed in 25 of 44( 56.8 %) cases. (2)There was no significant difference in expression of BCRP between the primary and metastatic sites (P>0.05). (3)Kaplan Meier analyses revealed that BCRP expression in primary breast carcinoma and metastatic lymph nodes didn′t associate with disease free survival (DFS) or overall survival (OS) (P>0.05).Conclusion The BCRP expression in metastatic lymph nodes may not reflect an aggressive biologic behavior in breast cancer.