泌尿道感染菌群分布及耐药性分析

Bacterial distribution and antimicrobial resistance in urinary system infection

目的 :研究我院肾内科 2 0 0 1～ 2 0 0 2年 2年期间从临床尿标本病原菌 (489株 )的菌群分布和药敏情况 ,为合理应用抗生素提供依据。方法 :细菌按常规方法分离鉴定 ,药敏采用K -B法。结果 :4 89株菌中革兰氏阴性杆菌 30 7株 ,占 6 2 .5 % ,主要以大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌、产气肠杆菌为常见 ;革兰氏阳性球菌 182株 ,占 37.5 % ,主要以肠球菌和血浆凝固酶阴性的葡萄球菌为主。药敏试验表明 :革兰氏阴性杆菌共同敏感的药物是亚胺培南、哌拉西林 /他唑巴坦 ;革兰氏阳性球菌共同敏感的药物是万古霉素、替考拉宁。结论 :泌尿道感染以大肠埃希菌和肠球菌为主 ,定期系统的细菌耐药监测对临床用药具有重要意义。

Objective:To study bacterial distribution and antimicrobial resistance of 489 strains of bacteria isolated from clinical urinary specimens of inpatients in department of kidney diseases of our hospital from 2001 to 2002,and propose rational use of antibiotics.Methods:Bacteria was isolated and identified by routine methods.Antimicrobial susceptibility was tested by K-B method.Results:in the 489 strains,there were307 strains of gram-regtive bacilli which account for 62.5%,mean while,there were 182 strains of gran-positive cocci which acconnt for 37.5%.The gram-negative bacilli mainly included K.pneumonice P.mirabilis and E.aerogenes.And the gram-positive cocci mainly included enterococcus and serum coagulase negative staphylococcus.The gram-negative bacilli were sensitive to imipenem and piperacillin/tazobactam,while the gram-positive cocci were sensitive to vancomycin and Teicoplamin.Conclusion:The urinary system infection is always induced by E.coli and Enterococcus.The periodical detection for bacterial resistance has an important significance for clinical treatment.