抗坏血酸在兔类固醇性高眼压中保护作用的研究

Protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbit

目的 :研究抗坏血酸在类固醇性高眼压发病中的作用。方法 :2 0只兔分为四组 ,每组 5只。观察四组实验动物眼压变化与时间关系。测定房水抗坏血酸浓度 ,眼球制作病理切片。结果 :单独使用地塞米松组兔眼压显著升高 ,房水中抗坏血酸浓度明显低于其它组 ;联合使用地塞米松及抗坏血酸眼压略有升高 ,后期有下降 ,小梁网出现轻微病理改变。结论 :局部使用皮质类固醇药物治疗时 ,同时局部给予抗坏血酸 ,可延缓和减轻类固醇性高眼压的发生。

Objective:To investigate the protective effect of ascorbic acid on dexamethasone-induced intraocular hypertension in rabbits.Methods:20 white rabbits were divided into four groups,with 5 in each one group.Every group was treated differently.Their intraocular pressure (IOP) and ascorbic acid concentration of aqueous humors were detected.Their eyeballs were studied for morphologic analysis.Results:There were statistical difference in IOP and ascorbic acid concentration of aqueous humors between the trial group subconjunctivally injected with dexamethasone and control groups.Their histological changes were significantly different.Conclusion:Subconjunctival injection of ascorbic acid can delay and alleviate the dexamethasone-induced intraocular hypertension in rabbits.