摘要
基因敲除技术是近年来发展起来的一种新兴的技术。它运用分子生物学的手段去除某一特定的基因制成基因敲除动物模型 ,通过这一模型来探究疾病的发病机制和病理特征 ,为疾病的预防、诊断和治疗提供依据。这一技术被成功地用于药物作用新靶点的发现 ,为疾病的治疗提供全新的机制。本文回顾了近年来基因敲除技术的最新研究进展 ,指出基因敲除技术将对创新药物的发现产生极大的促进作用 ,具有巨大的潜力 。
Gene knockout is a newly developed tec hnique in recent years The gene knockout model is developed by knockout specific gene using molecular biology m ethod The model has been successfully used to investigate the pathogenesis an d pathological characteristics of diseases which will provide a scientific basi s for prevention,diagnosis and treatment of diseases The tec hnique has been also successfully applied to the finding of new target for drugs which will provide novel mechanism for the therapy of diseases The paper revi ews t he recent advances in gene knockout technique and its application in the findin g of new targets for drugs. It also stress that the application of t his techniq ue in new drug development will bring about a great advance in new drug develo pment and may achieve breakthrough in alternative ways for treatment of some diseases
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2004年第1期1-6,共6页
Journal of China Pharmaceutical University
基金
国家自然科学基金(编号 :39970 86 2 )
国家 973基金 (编号 :1 9980 51 1 1 9)
国家 86 3计划 (编号 :2 0 0 3AA2Z34 7A)
江苏省药物代谢动力学重点实验室资助项目(编号 :BM2 0 0 1 2 0 1 )~~