中老年高血压患者216例脉压与冠心病危险性的相关分析

Correlation analysis of Pluse Pressure(PP) and risk of coronary heart disease (CHD) in 216 Patients with hypertension

目的 :研究不同脉压时冠心病发病率的变化。方法 :回顾性分析了 2 1 6例中老年高血压病患者的脉压 ( PP)与冠心病发生的相关性。结果 :1冠心病组在年龄、高血压病程和冠心病危险因素 (吸烟、饮酒、糖尿病 )暴露比例上显著高于非冠心病组。2根据脉压 PP<5 0 mm Hg,5 0 mm Hg≤ PP<80 mm Hg,PP≥ 80 mm Hg 3组间经方差分析 ,SBP,DBP之间存在显著性差异 ( P<0 .0 1 )和 ( P<0 .0 5 ) ;而 MBP之间无差异 ( P>0 .0 5 )。随着 PP值增大 ,SBP逐渐增大 ,DBP逐渐降低。 3 3组间随着 PP值增大 ,冠心病的发生率随之增加 ,经卡方检验( P<0 .0 5 )。结论 :在中老年高血压病人中 ,随着脉压增大 ,SBP增大 ,DBP降低 ,冠心病的发病率呈显著增加趋势 ,PP与冠心病发生呈显著正相关。

Objective: To explore the changes of the morbidity of coronary heart disease (CHD) in different pulse pressure(PP).Methods: 216 patients with hypertension from 50 to 79 years old were investigated retrospectively to determine the correlation between coronary heart disease and pulse pressure.Results:The ratio of risk factors(age, smoking, drinking, diabetes mellitus , duration of hypertension)in patients with coronary heart disease was much higher than that in control. According to the degree of pulse pressure(PP), the patients were divided into three grade groups as follows PP<50mmHg ,50mmHg≤PP<80mmHg ,PP≥80mmHg. There was significant difference between systolic blood pressure(SBP)( P <0.01) and diastolic blood pressure(DBP)( P <0.05)among the three grade groups. but, no difference in mean blood pressure(MBP)( P >0.05).With the rise of pulse pressure, SBP increased and DBP decreased gradually. The morbidity of coronary heart disease progressively increased with the elevated pulse pressure( P <0.05).Conclusion: Following the elevated pulse pressure, the incidence of CHD is positively related to PP.