非霍奇金淋巴瘤survivin和Ki67的表达及意义

Significance and Expression of survivin Protein and Ki67 in Non-hodgkin′s Lymphoma

目的 探讨survivin蛋白、增殖相关抗原Ki 67在不同恶性度非霍奇金氏淋巴瘤 (NHL)中的表达及意义。方法 应用免疫组织化学envisionsystem法检测NHL组织中survivin蛋白和Ki 67的表达。结果 在反应性增生淋巴组织 (LNRH)中未检测到survivin蛋白表达。在NHL中survivin蛋白表达率为 51.9% (2 8/ 54) ,其中低度恶性及中高度恶性组NHL中的表达率分别为 19% (4/ 2 1)、72 .7% (2 4/3 3 ) ,两组之间比较差异有显著性 (P <0 .0 0 1)。survivin、Ki67表达与恶性度均显著相关 ,而且survivin表达也与Ki67指数相关。结论 survivin蛋白在NHL患者组织中高表达 。

Objective To explore the expression of survivin and Ki67 in malignant non hodgkin′s lymphom(NHL) cells with variable aggressiveness and its clinical significance. Methods Immuno histochemistry stain methods envision system was used to detect the expression of survivin and Ki67.Results Survivin protein immunoreactivity was seen 0% in reactive hyperplasia of lymph node (LNRH) and 51.9% (28/54) in NHL.survivin expression increased with the tumor malignancy of NHL, there is a significant difference between the expression rate of survivin in low grade(19%,4/21) and intermediate to high grade NHL( 72.7% ,24/33)( P < 0.001 ). Both survivin and Ki67 LI had some relation with the grading of the NHL. The expression of survivin was positively correlated with Ki67 LI.Conclusion It suggested that the over expression of survivin was detected in NHL,survivin maight interfere with the antiapoptosis function impel the tumour formation.