幽门螺杆菌与胃癌关系的Meta分析

Meta-analysis of the Association Between Helicobacter pylori Infection and Gastric Cancer

目的 应用Meta 分析评价幽门螺杆菌 (helicobacterpylori,Hp)感染与胃癌发病的关系。 方法 纳入 3 6篇关于Hp感染与胃癌关系的文献 ,用Fleiss介绍的方法计算比值比 (OR值 )、95 %可信区间 (95 %CI)。 结果 经Meta 分析得出Hp感染与胃癌发病合并OR值为 2 3 7(95 %CI 2 14～ 2 61,χ2 =171 14 ,P <0 0 1)。早期胃癌与进展期胃癌的OR =2 2 5 (95 %CI 1 3 6～ 3 74) ;非贲门部胃癌与贲门部胃癌的OR =2 5 7(95 %CI 1 78～ 3 2 7) ;肠型与弥散型胃癌的OR =1 11(95 %CI 0 87～ 1 42 ) ;男性与女性胃癌的OR =1 0 5 (95 %CI 0 75～ 1 47) ;医院内的对照组与人群对照组的OR =0 92 ,(95 %CI 0 78～ 1 0 8)。结论 Hp感染是胃癌发生的危险因素 ,而造成各研究结果不一致的原因主要是胃癌的部位和发展阶段。

Objective To determine the association between Helicobacter pylori (HP) and the gastric cancer by Meta-analysis. Methods The paper collected 36 papers about the association between HP infection and the gastric cancer. Results The incorporated OR was 2.37(95%CI: 2.14-2.61,χ 2=171.14, P<0.01) by the Meta-analysis. The early vs. developing stage of the cancer, OR=2.25(95%CI: 1.36-3.74); Non-cardiac gastric cancer vs. cardiac gastric cancer, OR=2.57(95%CI: 1.78-3.27);Intestinal metaplasia gastric cancer vs. diffusion gastric cancer, OR=1.11(95%CI: 0.87-1.42); male vs. female, OR=1.05(95%CI: 0.75-1.47); The controls in hospitals vs. controls in population, OR=0.92(95%CI=0.78-1.08).Conclusion HP infection is one of the risk factors of gastric cancer and the differences in the studies' results were caused mainly by the cancer location and developing stage.