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抑癌基因的负转录调控 被引量:1

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摘要 抑癌基因在正常细胞中适度表达 ,抑制细胞永生及转化 ,其转录下调见于某些肿瘤 ,而在衰老细胞中常见表达上调或活性增强。抑癌基因INK4a/ARF、p5 3和p2 1Cip1的表达及其负调控与肿瘤及细胞衰老的关系十分密切。
出处 《生命的化学》 CAS CSCD 2004年第1期39-41,共3页 Chemistry of Life
基金 国家重点基础研究发展规划 (G2 0 0 0 0 5 170 0 1) 国家自然科学基金 (No .3 0 3 2 714 3 2 )
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