54例白血病血浆纤溶酶原及纤溶酶活性测定的临床意义

CLINICAL IMPLICATION OF PLASMINOGEN AND PLASMIN ACTIVITY IN LEUKEMIA A study of 54 patients

对54例白血病患者进行血浆纤溶酶原(PLG)及纤溶酶(PL)活性测定。结果表明:急性白血病患者血浆PLG含量低于正常对照(P<0.01),血浆PL活性高于正常对照(P<0.01);有临床出血的急性白血病患者PL活性显著高于无出血组(P<0.01)。患者血浆PL活性与纤维蛋白(原)降解产物(FDP)呈正相关(r为0.867,P<0.01),与纤维蛋白原(FG)含量呈负相关(r为-0.831,P<0.01)。6例慢性粒细胞白血病(CML)血浆PLG和PL活性与正常对照比较无显著性差异(P>0.05)。文中对急性白血病时血浆PLG及PL活性变化的可能原因及临床意义进行了讨论。

We measured the plasminogen(PLG)content and plasmin(PL)activity in 54 leukemic patients. The results showed that the PLG content was low and the PL activity was high in acute leukemia as compared with the normal controls, but they did not differ from the controls in chronic myelogenous leukemia. In the acute leukemia group, the PL activity was positively correlated with the plasms fibrin (fibrinogen)degradation products,(FDP) Ievel(r = 0.86,p<0.01) and negatively correlated with the fibrinogen(FG) concentration ( r = -0.83, p<0.01), and the PL activity was markedly higher in patients with bleeding than that without bleeding ( p<0.01 ) . The possible mechanism and clinical implications of the PLG and PL changes in acute leukemia are discussed.