摘要
本文选用6例乙型脑炎尸解脑组织,用ABC法及胶体金免疫电镜检测了脑组织内病毒抗原,IgM、IgG、IgA,补体C_3、C_4、淋巴细胞标志:T_3、T_4、T_8、Tac、B等项目。结果显示各病例血管壁内外、软化灶内、炎性病灶及胶质结节及一些较正常的组织内可检出C_3、C_4、IgM。神经元上可检出病毒抗原和IgM。在血管套,炎性病灶内检出T_3、T_4、T_8标记阳性细胞。在血管内可检出Tac、B标记细胞。作者认为:当特异性IgM与病毒抗原结合并在脑组织内沉积,激活补体系统,T细胞亦参与炎症反应,在清除病毒同时也引起脑组织免疫损伤。
The distributions of viral antigen, immunoglobulim ( IgM, Ig A, IgG ) , complement (C3, C4) and lymphocytic markes (T3, T4, Ts, Tac, B) were studied in the brains of 6 childrens who died Japanese eneephaltis. Both immuno-histochemical methods and immuno gold electron microscopy were performed in this researches. C3, C4, IgM were localized to foci of necrosis, inflamed foci, glial nodules and around blood vessels. T3, T4, T8 were detected in the perivasoular cuff and foci of inflammatory cells. Tac, B were detected in blood vessels. It was demostrated that combining differential IgM with viral antigen, activating complement and T lymphocytes, caused inflammatory reactions, eliminated virus,also caused immune brain damages.
出处
《徐州医学院学报》
CAS
1992年第3期201-204,239,共5页
Acta Academiae Medicinae Xuzhou
关键词
乙型脑炎
病理解剖学
脑损伤
Japanese encephalitis
pathology
IgM, C3, C4, viral antigen
Brain damage
Immunopathology
Children
