侧脑室注射去甲肾上腺素对大鼠应激性胃溃疡的影响

EFFECT OF CEREROVENTRICULAB INJECTION OF NOREPINEPHRINE ON STSESS GASTRIC ULCER IN RATS

用束缚+浸水应激模型,观察了侧脑室内注射去甲肾上腺素(NE)对大鼠应激性胃溃疡的影响,并对其作用机制进行了初步的探讨。结果为:侧脑室内注射NE后,能明显减轻大鼠应激性胃溃疡,并似有剂量一效应依赖关系;脑室内和皮下注射酚妥拉明及心得安后,能阻断NE的效应;室旁核内分别注射NE及心得安,能各自减轻和加强应激性胃溃疡的发生。这些结果表明,脑内NE可能通过室旁核的作用,参与了对应激性胃溃疡的调节。

The effect of intra-ccrebroventricular ( icv ) injection of norepinephr-ine (NE ) on the stress gastric ulcer induced by RWIS (restraint and water immersion stress) in rats was investigated . The main results were as follows : ( 1 ) A dese-dependent decrease of stress gastric ulcer was produced when NE icv was infused; ( 2 ) The protective effect of NE on the stress gastric ulcer was abolished by phentolamine and propranolol injected icv or subcutaneously; (3) The brain NE could inhibite paravent-ricnlar nucleus,likely by acting on the adrenergic β-receptors of its neurons. These results suggest that NE in the brain participats in the regulation of stress gastric ulcer and this action might be produced through the paravent-ricular nucleus.