精神分裂症患者外周血淋巴细胞姊妹染色单体交换的初步观察

A PRIMARY STUDY OF SISTER CHROMATID EXCHANGES (SCE) IN PERIPHERAL LYMPHOCYTES IN SCHIZOPHRENIA

检测了18例精神分裂症患者和25例健康人的SCE频率,结果提示患者组SCE频率显著高于对照组,与年龄、性别、病程、临床类型、有无遗传家族史无明显相关。研究提示SCE频率增高似与疾病本身有关。

SCE frequencies were studied in 18 selected untreated schizophrenia patients and 25 healthy persons to explore the interrelationship between schizophrenia and the factors which might result in DNA damage. The results indicated that SCE frequency was significantly higher in the schizophrenia group than in the control ( P<0.05) . The increase could be related to schizophrenia. No significant differences were found between the patients' sexes、 ages、 clinical subtypes or the stages of the Gisease. Genetical and family histories were not found to be related to SCE frequency either.