78例睡眠呼吸暂停综合征患者的睡眠特征及其与夜间低氧血症的关系

The Study of Sleep Structure and Hypoxemia in 78 Patients with Sleep Apnea Syndrome

目的 :了解SAS患者的睡眠特征及其与夜间低氧血症的关系。方法 :采用PSG对 78例SAS患者和 30例正常对照者进行整夜睡眠监测 ,比较两组间的睡眠特征。并对不同严重程度的夜间低氧血症SAS患者进行睡眠变量比较 ,分析二者的关系。结果 :与正常对照者相比 ,SAS患者夜间睡眠结构紊乱 ,主要为深睡眠减少、浅睡眠相对增加、REM睡眠减少、觉醒增加、睡眠潜伏期缩短、呼吸暂停或低通气次数增加、动脉血氧饱和显著下降 (P <0 .0 5 )。SAS患者夜间最低血氧饱和度与夜间总睡眠时间、睡眠效率、NREM睡眠时间及呼吸紊乱指数呈显著负相关 (r>0 .3,P <0 .0 5 ) ,与觉醒比例呈显著正相关 (r >0 .5 ,P <0 .0 1)。结论 :SAS患者睡眠结构紊乱突出 ,夜间反复发作的低氧血症对睡眠质量产生较大影响。

Objective: To explore sleep structure and hypoxemia of patients with sleep apnea syndrome (SAS). Methods: Seventy-eight adult patients with SAS and thirty normal controls were evaluated with polysomnogram (PSG). Results: The PSG confirmed the presence of a disrupted sleep pattern in SAS, including increased percentage of stage 1 sleep and wakefulness, decreased sleep efficiency, SWS, REM and sleep latency. The severity of hypoxemia in SAS related negatively to total sleep time, sleep efficiency, NREM sleep time and AHI, and positively to percentage of wake time at night. Conclusion: It suggested that patients with SAS had disrupted sleep pattern, which would be affected by hypoxemia.