叶酸对急性心肌梗死患者血清同型半胱氨酸及C反应蛋白的影响

The effects of folic acid on plasma homocysteine and C-response protein of patients with acute myocardial infarction

目的 :观察急性心肌梗死 (AMI)患者急诊经皮冠脉成形术 (PTCA)后口服叶酸对血清中 C反应蛋白 (CRP)及同型半胱氨酸 (Hcy)浓度的影响 ,进而为叶酸在 AMI患者中的应用提供依据。方法 :选择行急诊 PTCA的 AMI患者共 2 4例 ,分为两组 ,其中一组给予叶酸 5mg,1次 /d口服 ,另外一组不予叶酸口服 ,其余常规治疗均相同。分别在治疗前及治疗后取血测定血清中叶酸、Hcy、CRP的浓度并加以比较。结果 :治疗后 Hcy的浓度在叶酸组 (8.3±1.7μmol/L)及对照组 (11.3± 7.2 μmol/L)均有下降 ,差异均有统计学意义 ,但是叶酸治疗组的 Hcy浓度下降更多 ,二者的差异有显著性。治疗后血清中 CRP的浓度在叶酸组 (4.7± 3 .9mg/L )及对照组 (3 .7± 2 .0 mg/L )均较治疗前下降 ,差异有统计学意义 ,但是两组间 CRP下降程度的差异没有统计学意义。结论 :及时补充叶酸可以更有效地使 AMI患者血清中 Hcy的浓度下降 ,但并不能使血清中

AIM:To investigate the effects of folic acid on the plas ma homocystein e and C-responds protein of patients with acute myocardial infartion (AMI), so as to provide evidence for prompt application of folic acid to AMI patients. METHODS:24 cases were selected and divided into two groups. All of the m underwent percutaneous transluminal coronary angioplasty immediately after diagn osised. Then one group were given folic acid orally (5 mg/d) in addition to ro utine treatment , and the other group were treated with routine treatment only. Th e bl ood sample of the two groups were assayed pre- and post-treatment (two weeks l ater ), and the concentrations of folic acid, homocysteine and CRP were measured and co mpared. RESULTS:The Hcy concentrations of post-treatment were low er than those of pre-treatment in both groups, but the lowering degree in the folic acid gr oup was greater than those of the c ontrol group and the difference is significant (P<0.05). The concentrations of CRP o f post-treatment in both groups were lower than those of pre-treatment, and th e diffe rence was significance (P<0.05), but the lowering degrees of both groups wer e not si gnificantly different. CONCLUSION:Taking folic acid in time after AMI could lowe r the Hcy concentration more efficiently, but couldn't lower the CRP concent ration.