急性冠脉综合征患者血浆P-选择素的变化及意义

The relation of plasma P-selectin to acute coronary syndromes

目的 :探讨 P-选择素在急性冠脉综合征 (ACS)发生、发展中的作用 ,以及脂代谢对 P-选择素的影响。方法 :采用 EL ISA法检测 94例 ACS患者 [其中 AMI 3 2例、不稳定型心绞痛 (UA) 62例 ]及稳定型心绞痛 (SA) 18例和健康成人 18例的血浆 P-选择素水平。同时把 P-选择素与血脂结果作相关分析。结果 :血浆 P-选择素在 AMI、UA、SA和正常组的水平分别为 19.3± 5.0、15.3± 5.2、 11.1± 4.3和 10 .1± 3 .5μg/ L ,ACS组的 P-选择素高于 SA组和正常组 (P<0 .0 5)。而在 ACS患者中 ,AMI组的 P-选择素又高于 UA组 (P<0 .0 5)。血脂结果在 4组间比较均无显著性差异 ,但相关分析显示 ,L DL -c与 P-选择素呈正相关 (r=0 .3 6,P=0 .0 2 8)。结论 :P-选择素与 ACS的发生有关 ,其水平可反映 ACS的严重性 ;L

AIM: To explore the effect of P-selectin on the pa thogenesis and the development of acute coronary syndromes(ACS),and the influence of lipid metaboli sm on the plasma P-selectin. METHODS: We measured the levels of plasm a P-selecti n of 94 patients with ACS,18 with stable angina(SA),18 apparently healthy adul ts with ELISA.Then the correlations of P-selectin to TG?TC?LDL-c ?HDL-c wer e analyzed. RESULTS:The plasma levels of P-selectin were higher in A MI group an d unstable angina( UA) group than in SA group and control group(19.3±5.0 and 15 .3±5.5 μg/L vs 11.1±4.3 and 10.1±3.5 μg/L,P<0.05). Among the patien ts with ACS ,the plasma P-selectin level of AMI group was higher than that of UA group(P <0.0 5).No significant differences of lipid levels in each group were found(P>0.0 5),but there was a positive correlation between the LDL-c and the P-selectin l eve l( r=0.36,P=0.028). CONCLUSION:The study suggests P-selectin i s associated with t he pathogenesis of ACS and reflects the severity of ACS;LDL-c involves the act ivation of platelets.