冠心病患者血液流变学和氧化低密度脂蛋白变化及其相关性分析

Changes in hemorrheology and their correlation with the changes in oxidated low-density lipoprotein in coronary heart disease patients

目的 :观察冠心病患者血液流变学、氧化低密度脂蛋白、氧自由基变化及其相关性。方法 :择期开腹手术患者64例 ,冠心病组和对照组各 3 2例 ,同时监测血液流变学的变化、氧化低密度脂蛋白 (ox-L DL )、脂质过氧化物(L PO)和超氧化物歧化酶 (SOD)等指标。结果 :冠心病组全血高切黏度、低切黏度、红血细胞压积、红细胞变形指数和 ox-L DL,均显著高于对照组 (P<0 .0 5或 P<0 .0 1) ;且全血高切黏度、低切黏度及红血细胞压积与 ox-L DL 间呈显著正相关 (P<0 .0 5) ;与对照组相比 ,冠心病组 L PO活性增高 (P<0 .0 5) ,SOD活性降低 (P<0 .0 5)。结论 :冠心病患者在血液流变学异常变化的同时 ,伴有 ox-L DL 和 L PO活性增高 ,SOD活性降低 ,且血液流变学变化与 ox-L

AIM: To observe the changes in hemorrheology and their correlat ion with the changes in oxidated low-density lipoprotein (ox-LDL) and free radical in coronary heart disease pa ti ents. METHODS: 64 patients who had undergone abodominal surgery were randomly divided i nto 2 groups:the coronary heart disease group (n=32) and the control group( n=32 ). And the changes in hemorrheology, ox-LDL, lipoperoxide (LPO) and superoxide di s mutase (SOD) were observe. RESULTS: The whole blood high-sheard visc osity, low-sheard viscos ity, hematocrit, distortion index of red blood cells and ox-LDL were significan tl y higher in the coronary heart disease group (P<0.05 or P<0.01), and the re was posit ive correlation between high-sheard viscosity, low-sheard viscosity, hematocri t and ox-LDL (P<0.05). Compared with the control group, the activity of LPO i ncreased (P<0.05) and the activity of SOD decreased (P<0.05) in the coronary hear t disease gr oup. CONCLUSION: There were abnormal changes in hemorrheology in the coronary heart d isease group, with the activities of ox-LDL and LPO increasing and the activity of SOD decreasing. And the changes in hemorrheology were correlated with ox-LD L.