育成鸡有机硒中毒实验研究

THE STUDIES OF EXPERIMENTAL ORGANIC SELENIUM TOXICOSIS IN GROWING CHICKENS

本试验用硒中毒地块玉米进行了实验研究,结果表明:试验Ⅰ组(日粮含Se8.06ppm)、Ⅱ组(日粮含Se 13.08ppm)于饲喂后第9天出现了中毒症状,第43天出现了死亡,对照组(日粮含Se 0.1164ppm)发育良好,无异常表现;第10天试验Ⅰ、Ⅱ组Se GSH-px活性明显升高,组间差异显著(P<0.05);试验Ⅰ组迫杀和试验Ⅱ组死亡鸡组织中硒含量明显高于对照组(P<0.01),组间差异显著(P<0.01),组织中硒水平顺序为肝>肾>胸肌>心肌;病理变化试验组以肝脏灶状坏死、心肌萎缩变性、肾曲细管上皮细胞变性坏死为主,对照组未见明显的一致性病变。

The experimental growing chickens were fed with corn grain in Se-poisoning area. GroupⅠ ( Se 8.06ppm in rations ) and groupⅡ ( Se 13.08 ppm ) developed poisoning symptoms after 9 days,and died in 43 days. GroupⅢ ( Se 0.1164ppm ) was used as control, the growing chickens exhibited not abnormal. The activity of blood GSH-px increased significantly on 10th day after Se administration in group Ⅰ and Ⅱ, and difference existed between group Ⅰ and Ⅱ ( P<0.05 ) . The Se content in growing chicken organs in group Ⅰ and Ⅱ was higher than in the control (p<0.01). And difference existed between group Ⅰ and Ⅱ ( p<0.01 ) . of tissues from poisoning growing chickens, the Se content was highest in the liver, followed by the kidney, breast muscle and myocardium. The predominant pathologic changes occured in these growing chickens was characterized by local necrosis in liver, myocardium degeneration and convoluted tubule necrosis in kidneys. No changes were observed in the control.