软药原理与新药设计

Principles of Soft Drug and New Drug Design

探索软药原理在新药研究中的规律,推动新药研究工作的开展,通过文献检索分析比较、归纳综合,阐述软药的意义、分类及在新药设计中的典型事例和软药原理在新药设计中广泛应用。该原理依据有效药物的代谢机理进行的新药设计,其特点是在体内一步代谢失活,缩短药物的体内过程,将药物的药效与药物的毒副作用分开,提高了药物的治疗指数。它比全新药物的创制难度低、风险小、命中率高,是新药研究的一条重要途径。

Through indexing the document,we can syenthesize and analyse the standard examples of soft drug principles in the new drug design.The paper explores, the law of soft drug principles in the new drug to promote the develepment of the drug research.The principles,based on the effective drug in vivo metabolism,can be applied in new drug design,and it has the features of further activating metabolism,shortening the period of drug's stay in body,and seperating the effect and by-effect of the drug,thus improving the effective index of the drug.Compared with the brand-new drugs,it is easy to manufacture,with low risk,but high accuracy,therefore,it is an important method of new drug research.