硫酸吗啡与盐酸吗啡普通片对照治疗中、重度癌痛84例

Comparative study of the analgesic effect of morphine sulfate and morphine HC1 tablets in treatment of 84 patients with moderate to severe cancer pain

目的:评价硫酸吗啡与盐酸吗啡普通片对癌症疼痛的镇痛疗效及不良反应。方法:采用多中心随机对照试验,试验组(n=44)用硫酸吗啡,对照组(n=40)用盐酸吗啡,起始量均为10-30mg,每4-6h用1次,进行个体剂量滴定,达到无痛或基本无痛的维持量继续应用,共7d。结果:2组的疼痛完全缓解率分别为77.3％与77.5％,显著缓解率为95.5％与97.5％,总有效率为100％。结论:硫酸吗啡与盐酸吗啡片治疗中、重度癌痛均有显著疗效。

Objective: To study the analgesic effect of morphine sulfate and morphine HCl tablets in treatment of moderate to severe cancer pain. Methods: Patients with cancer pain were initially treated with 10-30mg every 4-6 hours morphine sulfate or morphine HCl tablets. Then the dose was titrated individually to no pain or basically no pain and maintained for 7days. Results: The complete pain relief rate for the 2 groups was 77. 3% and 77. 5 % with a total effective rate of 100% . Conclusion : Both the morphine sulfate and morphine HCl tablets are highly effective in treatment of moderate to severe cancer pain.