阿托伐他汀对高脂血症患者颈动脉内膜中层厚度及凝血系统的影响

Effect of Atorvastatin on Intima-media Thickness of the Common Carotid Artery and Blood Coagulation in Hyperlipidemic Patient

目的 观察阿托伐他汀调脂同时对高脂血症患者颈动脉内膜中层厚度 (IMT)及凝血系统的影响。方法 选择高脂血症患者 35例为血脂紊乱组 ,口服阿托伐他汀 10mg·qd ,12周 ,血脂正常者 35例为正常对照组 ,分别对血脂紊乱组治疗前及 12周后两组进行血脂总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、IMT、纤维蛋白原 (FIB)、凝血酶时间 (TT)、活化部分凝血酶时间 (APTT)、凝血酶原时间 (PT)检查。结果 与治疗前比较 ,血脂紊乱组治疗 12周后的TC、TG、LDL C、FIB均有显著降低 (P均 <0 0 1) ,HDL -C显著升高 (P <0 0 5 ) ,颈动脉IMT显著变薄 (P <0 0 5 ) ,TT、APTT均有显著延长 (P均 <0 0 1)。PT显著升高 (P <0 0 5 )。TC、TG、LDL C、HDL C、IMT、FIB、PT均接近血脂正常组各指标 ,比较无显著差异 (P >0 0 5 )。TT、APTT均超出血脂正常组 ,比较有显著差异 (P <0 0 5 )。结论 阿托伐他汀在有效调脂同时可发挥其非调脂作用 ,逆转或延迟颈动脉IMT的进程 ,并改善凝血系统。

Objective To study the effect of atorvastatin on intima-media thickness(ITM)of the common carotid artery and coagulative system in hyperlipidemic patierts. Methods Thirty five hyperlipidemic patients were received atorvastatin 10 mg qd for 12 weeks. TC,TG,LDL-C,HDL-C,IMT,fibrinogen(FIB),thrombin time (TT),activated partial thromboplastin time(APTT) and prothrombin time (PT) were determind in hyperlipidemic group before and after treatment. The intima-media thickness of carotid artery was measured using echography. Thirty-five normol lipidemic subjects serued as control. Results TC,TG,LDL-C,IMT,FIB were decreased significantly( P< 0.01)in hyper-lipidemic group after 12 weeks. HDL-C,PT TT,APTT were increased significantly ( P< 0.05). Compared with normal lipidemic group,TC,TG,LDL-C,HDL-C,IMT,FIB and PT were not significantly different( P> 0.05),while TT,APTT were significantly increased ( P< 0.05). Conclusion Atorvastatin treatment not only regresses the structural changes in IMT of the common carotid artery but also improve disorder of coagulation system in hyperlipidemic patients.