脑梗塞后抑郁与梗塞部位的关系及治疗

Related factors ot location of cerebral infarction and therapy of depression after cerebral infarction

目的:研究脑梗塞后抑郁症的发生率及其与梗塞部位及数量的关系及治疗效果。方法:采用SDS抑郁自评量表及HAMD抑郁量表筛查后统计发生率并用统计法对梗塞部位和数量进行分析,观察帕罗西汀治疗前及治疗4周后效果。结果:总发生率为35.7％,多发性梗塞、前部脑梗塞及皮质部脑梗塞的患者抑郁发病率高。帕罗西汀可显著改善或治愈脑梗塞后抑郁,总有效率为62.2％。结论:梗塞后抑郁发病率高,抑郁发生和梗塞部位及数量相关。帕罗西汀治疗有效。

Objective: To investigate the incidence of post-cerebral infarction depression and its relation to infarction location and number and therapy of depression. Methods: Patients were assessed by SDS and HAMD in order to analyze the incidence and its relation to infarction. To compare the curative effect before and after therapy of fluoxetine . Results: The incidence of depression is 35.7%. Partents with multiple infarction, forehead infarction and cortex infarction tend to be depressed, fluoxetine is effective to depression after cerebral infarction. The cure rate is 62. 2% . Conclusions: The incidence of post-cerebral infarction depression is high and related to the number and location of infarction. fluoxetine is effective to depression after cerebral infarction.