摘要
综述了近10国内外关于Ⅱ型糖尿病人认知功能特点的研究.结果表明:(1)流行病学筛查因天花板效应难以发现认知损伤.(2)采用对年老化较敏感的行为学指标证实,60~70岁的糖尿病人认知能力显著低于对照组;但60岁以下或70以上病人则少有类似表现.认知阈限理论可解释这一年龄相关现象.(3)Ⅱ型糖尿病人认知功能损伤主要表现为语词记忆损伤、学习能力下降、脑电(P300)潜伏期延长等.(4)认知损伤程度与血糖和胰岛素水平相关,也受高血压等共病因素的影响.控制糖代谢可改善认知功能.糖尿病人的认知损伤与年龄相关,但其机制不同于正常年老化过程中的认知衰退.
Studies conducted in recent 10 years to study the cognitive impairments of patients with type 2 diabetes were reviewed. It was confirmed that hyperglycemia can cause cognitive problem, although inconsistent conclusions still remain. Some studies found impairment while the others didn't. So far, most studies confirmed the impairment of learning and memory function in patients with type 2 diabetes. Cognitive threshold theory was used to explain the remain controversy, by which only the patients aged from 60 to 70 will display impairment compared with the controls. Reduced level of insulin in central nerves system was also studied. Reasons of cognitive impairment and more sensitive measurements were suggested.
出处
《心理科学进展》
CSSCI
CSCD
北大核心
2003年第5期562-566,共5页
Advances in Psychological Science
基金
中国科学院生物技术局特别支持项目(SKZ-01-13)
