54例SARS患者LDH、ALT、CRE和尿液变化及其临床意义

The changes and clinical significance of LDH,ALT,CRE and urine in 54 patients with severe acute respiratory syndrome

目的 探讨传染性非典型肺炎 (SARS)的部分实验室检查指标及其临床意义。方法 观察 5 4例SARS病例肝、肾功能生化指标 ,心肌酶谱以及尿蛋白 潜血试验 ,分析其特征 ,并和同期 37例普通肺炎 (CP)患者的相应指标相比较。结果 SARS组多项指标与CP对照组相比较有显著性差别。 5 4例SARS患者中 ,36例 (6 6 .7% )ALT升高 ,2 9例 (5 3.7% )出现LDH升高 ,12例 (2 2 .2 % )尿蛋白 潜血试验阳性。 2组CRE均无明显升高 ,差别无显著性 (P >0 .0 5 )。CP组有一定比例的LDH升高 (2 7.0 % ) ,但与SARS组相比差别有显著性 (P <0 .0 5 )。结论 SARS患者的部分实验室检查显示 ,超过半数病例的ALT、LDH出现明显的升高 ,相当一部分患者出现尿蛋白 潜血试验阳性 ,提示该病对肝、心及肾等多器官功能有损害。

Objective To investigate the laboratory characteristics and clinical significance of severe acute respiratory syndrome (SARS).Methods The biochemistry parameters in 54 patients with SARS, including the function of liver and kidney, myocardial enzymes,urinary protein and occult blood examination, were detected and compared with those of 37 patients with common pneumonia (CP).Results There were significant differences in these parameters between SARS patients and CP patients. Among 54 patients with SARS, there were 36 cases of ALT increase (66.7%),29 cases of LDH increase(53.7%),and 12 patients whose urinary protein and occult blood examination were positive. There was no significant difference in CRE between two groups (P>0.05).The LDH in part of CP group was increased (27.0%),however, which was significantly different from that of SARS group(P<0.05).Conclusion The ALT and LDH are increased in over half of patients with SARS, and urinary protein and occult blood examination are positive in part of patients, which suggests that SARS may cause injures to multiple organs including liver, heart and kidney.