溶脲脲原体感染导致大鼠泌尿道形成结石

Ureaplasma urealyticum infection induced the production of calculus in urinary and reproductive system of male rats

目的 :研究溶脲脲原体 (ureaplasmaurealyticum ,UU)感染对雄性大鼠泌尿生殖系统结石形成的影响 ,从而探究引起雄性大鼠泌尿生殖道结石形成的途径与机制。 方法 :采用模拟性交的自然方式使雄性SD大鼠反复感染UU。 8周末处死大鼠 ,解剖泌尿生殖系统 ,观察有无异常。 结果 :12 .5 %的大鼠尿道口及尿道中有白色略呈半透明的块状固体 ,质软 ,为软结石 ;2 7.5 %的大鼠膀胱中有结石 ,其中 12 .5 %为软结石 ,15 %为硬结石 ,结石的数目不等 ,少的数枚 ,多的十多枚 ;肾盂、曲细精管中未发现结石。 结论

Objective:To investigate affection of ureaplasma urealyticum (UU) infection on the production of calculus of the urinary and reproductive system in male rat. Methods:Sprogue-dawley(SD) rats were infected with UU4 (serotype 4) through repeated natural sexual intercourses for 8 weeks. The urinary and reproductive system were detected . Results:Twelve point five percents of rate infected with UU had soft calculus in urinary tracts, while 27.5 percents of rate infected with UU had soft or hard calculus. Conclusion: Infection with UU may lead to the production of calculus in urinary and reproductive system in male rats