安体舒通对充血性心力衰竭患者室性心律失常的作用

Effect of spironolactone on ventricular arrhythmias in congestive heart failure

目的 观察安体舒通对慢性充血性心力衰竭合并室性心律失常的作用。方法 32例慢性充血性心力衰竭合并室性心律失常患者随机分为两组 ,对照以地高辛、卡托普利、速尿等传统治疗 ,治疗组在对照组治疗的基础上加用安体舒通 2 0mg ,2次 /d ,口服。观察治疗前后血电解质及室性心律失常情况。 结果 加用安体舒通的治疗组在电解质平衡方面明显好于对照组 ,治疗组的室性早搏在治疗后明显减少 ,与对照组比较有显著差异 (P <0 .0 0 1)。

Objective:To investigate the effect of spironolactone on ventricular arrhymias complicated with chronic congestive heart failure.Methods: 32 patients with vetricular arrhythmias complicated with chronic congestive heart failure were divided randomly into two groups .The treatment group received spironolactone along with standard medical management using Digoxin,Captopril and furosemide, the contrast group only received standard medical treatment. The changes of electrolyte and episodes of ventricular arrhythmias were used to assess the effect.Results:There is a significant electrolytic balance in the spironolactone treated group in contrast to the negligible improvement in the contrast group.While the number of hourly ventricular premature beats and the episodes of non-sustained ventricular tachycardia per 24 hours decreased in both groups,the treatment group decreased more than the contrast group (P<0.001).Conclusion:Spironolactone is helpful in controlling ventricular arrhythmias in chronic congestive heart failure.