卵巢上皮性肿瘤血管生成的研究

Study on Angiogenesis of Epithelial Ovarian Neoplasms

目的 探讨不同性质卵巢上皮性肿瘤的血管生成情况及微血管生成与卵巢癌组织类型、病理分级、临床分期的关系。方法 采用免疫组化SP法。结果 卵巢肿瘤依良性、临界恶性、恶性的不同 ,其微血管密度 (MVD)依次升高。卵巢临界恶性肿瘤组与良性肿瘤组、正常卵巢组MVD均有显著差异 (P <0 0 5 ) ,而卵巢癌组与卵巢临界恶性肿瘤组 ,良性肿瘤与正常卵巢组的MVD无显著差异 (P分别为 0 3 4和 0 46) ,单因素采用生存率时序检验 (Logranktest)结果表明 ,MVD与卵巢癌预后无关 (Log -rankP =0 2 7)。结论 MVD在卵巢发生发展过程中起重要作用 ,可作为判断卵巢肿瘤恶性程度的一项指标 。

Objective To explore the angiogensis in epithelial ovarian neoplasms and the relationship among angiogenesis and clinical stage, the histological type and pathological grade of epithelial ovarian carcinomas. Methods The microvessel density (MVD) was examined in 74 cases of epithelial ovarian neoplasm and 20 nomal samples by using immunohistochemical SP method. Results MVD increased gradually from benign to borderline malignancy and ovarian carcinomas, and MVD there was a significant difference in between the borderline malignancies and benign tumors or normal tissues(P<0 05). But there was no siginificant differences in MVD between the ovarian carcinomas and borderline malignancies or benign tumors and normal samples(P=0 34 and P=0 46,respectively). Log rank test showed that no correlation was found between MVD and survival rate (Log-rank P=0 27). Conclusions Angiogensis may play an important role in pathogenesis and development of ovarian cancer, and MVD can be used as an index to estimate the malignant degree of ovarian neoplasms. MVD could not serve as an index to predict the prognosis of patients with epithelial ovarian cancer.