慢性阻塞性肺疾病558例肺功能特征分析

The Analysis of Lung Function of 558 Patients with Chronic Obstructive Pulmonary Disease

目的 分析慢性阻塞性肺疾病 (COPD)患者肺功能特征 ,并探讨各项肺功能指标在COPD诊断及病情评估中的意义。方法 对我院 2 0 0 1-0 1～ 2 0 0 3 -0 4诊治的 5 5 8例COPD患者的肺功能进行回顾性分析 ,并使用SPSS10 0软件对肺功能各指标进行分析。结果 COPD患者平均年龄 ( 5 7 6± 9 7)岁 ,以Ⅱ级及Ⅲ级患者居多 ,男性患者占 78 9%,明显多于女性 ,吸烟指数与FEV1 、FEV1 /FVC呈负相关 ,与Raw ,RV/TLC呈正相关 ,COPD高危期有MMEF、V50 及V2 5的下降 ,PEF、DLCO与FEV1 及肺功能其它指标均有良好的相关性。结论 肺功能检查是诊断COPD的金标准 ,FEV1 、FEV1 /FVC、MMEF、V50 、V2 5、Raw及RV/TLC均是反映COPD气流阻塞程度的指标 ,其中MMEF、V50 及V2

Objective To analyse the lung function parameters of the patients with chronic obstructive pulmonary disease (COPD) to explore the clinical significance of lung function in the diagnosis and evaluation of COPD. Methods The lung function of 558 patients with COPD from January 2000 to April 2003 in our hospital was retrospectively analysed by using SPSS 10 0 software. Results The average ages of the 558 patients were 57 6±9 7 years, 78 9% of which were male. Patients with grades Ⅱ and Ⅲ COPD accounted for 70 2%. There was a negative relationship between FEV 1, FEV 1/FVC and smoking index(r=-0 039,-0 305,P<0 01),and a positive relationship between Raw,RV/TLC and smoking index(r=0 291,0 320,P<0 01). MMEF, V 50 and V 25 decreased in patients with grade 0. PEF and DL CO were significantly associated with FEV 1 and other lung function indices. Conclusions Lung function is the golden standard in the diagnosis of COPD. FEV 1, FEV 1/FVC, MMEF, V 50 , V 25 , Raw and RV/TLC are indices which reflect the obsruction degree of COPD. MMEF, V 50 and V 25 obviously change in the early stage of COPD.