摘要
目的 探讨高脂血症模型与患者血脂、血糖和凝血因子的变化及其关系。方法 用家兔制作高脂血症模型 3 0例并在临床随机抽取高脂血症患者和正常人各 40例 ,检测其血脂、血糖和凝血指标 ,将结果进行比较。结果 高脂血症家兔模型和临床病例的TC、TG、LDL -C和Glu显著升高 (均P <0 0 1) ,APTT和Fbg具有显著变化 (均P <0 0 1) ,PT和TT无改变 (均P >0 0 5 ) ;而HDL -C在模型中增高 (P <0 0 1)、临床病例没有变化 (P >0 0 5 )。结论 高脂血症模型与患者的血脂变化有所区别 ,但两者均可伴有糖代谢异常 。
Objective To study the changes and correlations of the blood lipids, glucose and blood coagulation factors in the animal models and patients with lipodystrophia. Methods The models of hyperlipoidemia were set up in 30 rabbits, and 40 cases of the hyperlipoidemia and 40 cases of the healthy subjects randomly were enrolled in this study. Their blood lipids, glucose and coagulation factors were detected. Results The serum levels of TC,TG,LDL-C and Glu in the rabbit models and patients with hyperlipoidemia notably increased compared with controls(P<0 01). Their APTT and Fbg levels also showed remarkable change (P<0 01), which PT and TT levels had not chang(P>0 05). HDL-C level increased in the rabbit models(P<0 01), but did not change in the patients(P>0 05). Conclusions The change of the blood lipids level in the rabbit models was different from that of the patients with hyperlipoidemia. But both may company the abnormality of carbohydrate metabolism, and hyperlipoidemia may affect the endogenous blood coagulation system to cause the blood to present the high coagulation.
出处
《中国医师杂志》
CAS
2004年第2期217-218,共2页
Journal of Chinese Physician
基金
广东省中医药局基础研究项目 (40 1 0 4 5)
关键词
高脂血症
血脂
血糖
凝血因子
高凝状态
脂质代谢紊乱
Hyperlipoidemia
Animal model
Clinical case
Blood glucose
Blood coagulation factor