心力衰竭患者肌钙蛋白T及CK-MB与CK比值的动态变化

Dynamic changes of value of troponin T and ratio of CK -MB/CK in patients with chronic heart failure

目的:探讨慢性心力衰竭(CHF)患者肌钙蛋白T(TnT)及血清肌酸激酶同工酶(CK—MB)与肌酸激酶(CK)比值(B/K)的动态变化及临床意义。方法:测定80例不同病因所致的CHF患者和80例同期非心血管病对照组患者的肌钙蛋白T及血清肌酸激酶同工酶(CK—MB)与肌酸激酶(CK)的比值(B/K)。结果:CHF患者TnT水平较对照组升高(P<0.01);CK—MB、CK均在正常范围;随心功能不全的加重TNT、B/K比值逐渐升高,心功能不全Ⅳ级者较Ⅱ、Ⅲ级组,对照组有明显差异(P<0.01)。结论:CHF患者的TnT及B/K比值可考虑为评价心衰严重程度的参考指标。

Objective: To evaluate the clinical significance of dynamic changes of value of troponin T and serum creatine kinase isoenzyme and ratio of CK - MB/CK-activity (B/K) in patients with chronic heart failure (CHF). Methods: TnT, CK and CK - MB were measured in 80 patients with CHF and 80 patients without cardiovascular disease. Results: The value of TnT increased in CHF group than that of control group (P<0. 01). CK and CK -MB value of all patients were normal. Ratio of B/K in patients NYHA function class Ⅳ was higher than those in NYHA function class Ⅱ.Ⅲ (P<0. 01). Conclusion:The value of TnT and the ratio of CK - MB/CK activity may regard as index of cardiac function in patients with CHF.