纤维蛋白原浓度变化在急性冠脉综合征中的临床意义

Clinic significance of fibrinogen in acute coronary syndrome

目的:探讨血浆纤维蛋白原(Fg)浓度变化与急性冠状动脉综合征(ACS)的关系。方法:对37例稳定性心绞痛、32例不稳定性心绞痛、31例急性心肌梗死和42例正常对照者分别进行血浆纤维蛋白原浓度测定,并分组进行比较。结果:(1)冠心病各组Fg浓度显著高于正常对照组(P<0.01)。(2)冠心病各组之间随冠脉事件的严重程度,Fg有增高趋势,不稳定性心绞痛和心肌梗死组血浆Fg水平明显高于稳定性心绞痛组(P<0.05)。结论:Fg参与冠心病的发病过程,其升高对冠心病有一定的预测价值,Fg浓度与急性期冠脉事件和ACS严重程度可能相关。

Objective:To investigate the change of plasma fibrinogen content and the relationship with the acute coronary syndrome. Methods: The plasma level of fibrinogen was detected in 142 cases, including 37 patients with stable angina pectoris, 32 with unstable angina pectoris, 31 with acute myocardial infarction and 42 control subjects. Results: (1) The level of plasma fibrinogen in patients with coronary heart disease (CHD) was higher than that in control subjects (P<0. 01); (2) The level of fibrinogen in patients with ACS was higher than that in stable angina group(P<0. 05). Conclusion:The research showed that the change of fibrinogen content was involved in development of CHD, The elevated level of fibrinogen may be a predictor for the incidence of CHD and was closely correlated with acute ischemic events.